CIRCADIAN FIBRINOLYSIS SYSTEM IN THE FIRST HOURS OF ISCHEMIC STROKE

The research activity of fibrinolysis in 123 patients with ischemic stroke, of which 65 (52.8%) women and 58 (47.2%) males, mean age 72,6 ± 11,5 years. Main parameters evaluated fibrinolysis system (t-PA concentration and PAI-1 activity and plasminogen á2- antiplasmin, euglobulin lysis time determination and Hageman-dependent fibrinolysis). The highest activity of plasminogen was detected in patients who have ischemic stroke arose from 06:00 to 11:59 (89,42 ± 13,5%, 95% CI 85,35-93,49) and from 18:00 to 23: 59 (87,88 ± 8,8%, 95% CI 84,74-91,01), the lowest activity - from 24:00 to 5:59 (83,56 ± 6,1%, 95% CI 80, 31- 86.82). The activity of alpha- 2 antiplasmin also had some differences - the highest activity was registered from 24:00 to 5:59 (85,38 ± 4,7%, 95% CI 82,84-87,91), lowest at 18:00 59 to 23 (84,21 ± 10,0%, 95% CI 80,65-87,77). In cases patsentov from 06:00 to 11:59 was recorded the lowest average level of fibrinolysis activator t-PA 0,045 ± 0,02 USD / Ml (95% CI 0,039-0,052) and high concentrations of its inhibitor PAI-1 0,113 ± 0,05 USD / Ml (95% CI 0,099-0,128). Inhibition of fibrinolysis, was confirmed by the increase in lysis time euglobulin (7,97 ± 0,71 hours, 95% CI 7,76-8,19) and Hagemann-dependent fibrinolysis (23,09 ± 2,79 m, 95% CI 22,25-23,93). The activity of the fibrinolysis system in patients with ischemic stroke tsirkazhdni has certain peculiarities. The highest activity of plasminogen, amid lower t-PA concentration and high content of PAI-1 is registered in patients stricken from 06:00 to 11:59. These changes are responsible for a significant extension of the clot lysis time euglobulin and Hagemann-dependent fibrinolysis.