EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF METHANOLIC EXTRACT OF TAGETES ERECTA LEAVES ON CARBON-TETRACHLORIDE INDUCED HEPATOTOXIC RATS

The present study was conducted to evaluate the hepatoprotective effects of methanolic leaf extract of Tragetes erecta on carbon tetrachloride (CCl4) induced liver damage in albino rats. Wistar albino rats weighing around 180-200g were used. Toxicity was induced by using 30% CCl4 suspended in olive oil (1.0 ml/kg body wt intraperitoneal) after every 72 hrs for 3doses. The methanolic leaf extract at a dose of 250mg/kg was administered orally by intragastric tube for 10 days. Blood and liver tissue were collected for the assessment of serum marker enzymes such as ALT, AST and ALP. The liver tissue was used for histopathological assessment. Keywords: Tragetes erecta, CCl4, Alkaline phosphatase (ALP), Alanine amino transaminase (ALT), Asparate aminotrasaminase (AST).