INFLUENCE OF HYDROGEN SULFIDE ON ANALGESIC AND ANTI-INFLAMMATRY EFFECTS OF DICLOFENAC SODIUM IN EXPERIMENTS

Aim of the study: to determine the influence of H2S on the analgesic and anti-inflammatory effects of diclophenac sodium. Materials and methods. Analgesic and anti-inflammatory effect of the donor of H2S (1,5 mg/kg i.p.), diclofenac (8 mg/kg i.g) and their combinations was studied during electric pain stimulation, formalin test and carrageenan edemas. Results. The donor of H2S minimized inflammatory process, caused moderate antinociceptive effect in intact animals, and more significant analgesic effect in experimental inflammatory processes. Its introduction increased analgesic and anti- inflammatory actions of diclofenac sodium. Conclusion. The ability of H2S to modulate pharmacodynamics of NSAIDs may be a promising way of increasing the effectiveness and safety of pharmacotherapy with drugs of this group.