PREPARATION AND EVALUATION OF SIMVASTATIN ETHOSOMES

The purpose of the present investigation is aimed to prepare and evaluate simvastatin ethosomes containing different concentration of ethanol and phospholipids by sonication for size reduction of vesicles. Designed ethosomes are characterized for Size and shape, Entrapment efficiency, Release study and Stability study, The effect of sonication also studied on the characteristics of simvastatin ethosomes. To formulate ethosomal gel, characterize the prepared formulation using cold method and carryout various evaluation parameters which includes vesicular shape and surface morphology, vesicular size, size distribution, drug content, storage-physical stability of ethosomes, entrapment efficiency and in vitro drug diffusion study of ethosomal gel. Key words: ethosomes, phospholipids, sonication, gel and cold method.