NOVEL DRUG DELIVERY APPROACHES FOR COLONIC DRUG DELIVERY SYSTEM: A REVIEW

Colon related diseases is the world-wide health problem in which Colorectal cancer is the second most dangerous type of cancer, affecting both men and women. The modern diet and lifestyles, with high meat consumption and excessive alcohol use, along with limited physical activity has led to an increasing mortality rate for colon cancer worldwide. As a result, there is a need to develop novel drug therapies for colon related diseases. Colon specific drug delivery system (CDDS) has attracted significant attention during the past 20 years in providing several therapeutic advantages particularly for drugs that are sensitive to acidic condition and to intestinal enzymes. The colon is a site where both local and systemic delivery of drug can takes place. Oral drug delivery to treat colonic diseases encounters many problems like drug stability in the harsh environment of upper GI tract. Sustained colonic release of drugs can be useful in the treatment of nocturnal asthma, angina and arthritis while site specific release strategy is needed for local action for condition involving colonic pathologies such as ulcerative colitis, colorectal cancer and crohn’s diseases. This review is focused on primary and novel drug delivery formulation and approaches for colonic drug delivery through pH sensitive system, microbially triggered system, time release system, osmotically controlled drug system, pressure dependent release system, probiotic approach, chronotropic system, Pulsincap system, prodrug approach, Enterion capsule based system, port system, CODES™ approach, COLAL-PRED approach, multiparticulate based system. Keywords: CDDS, Ulcerative colitis, colorectal cancer, CODES™.