ResearchBib Share Your Research, Maximize Your Social Impacts
Sign for Notice Everyday Sign up >> Login


Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.03, No. 07)

Publication Date:

Authors : ; ; ;

Page : 713-727

Keywords : Telmisartan; chitosan; gellan gum; cross povidone; micro crystalline cellulose; sodium starch glycolate; Mouth dissolving tablets.;

Source : Downloadexternal Find it from : Google Scholarexternal


The aim of this research is to prepare and evaluate the Mouth dissolving tablet of Telmisartan introducing the use of newly arising natural excipient as a superdisintegrants .The applied Naturat superdisintegrants(chitosan and gellan gum) has versatile property in the Mouth disintegrating tablets using Telmisartan as model drug. Mouth disintegrating tablets are the useful formulations for pediatrics, geriatric, and physically and mentally disabeled patients resulting in improved patient compliance. Telmisartan is an antihypertensive drug which belongs to the class of Angiotensin Receptor ΙΙ (Type- ATΙ) Antagonist. It is a poorly soluble drug (BCS class-II) and its absorption is dissolution rate limited. The oral bioavailability of Telmisartan is 45%. Hence, in this research an attempt was made to develop Mouth dissolving tablets of Telmisartan formulated with natural disintegrating agent and superdisintegrants(synthetic) combination with superior dissolution properties. The aim is to formulate various batches of mouth dissolving tablets of Telmisartan by using chitosan, gellan gum, microcrystalline cellulose, crospovidone and sodium starch glycolate with different concentrations by direct compression. The tablets were evaluated for the precompression parameters such as bulk density, compressibility, angle of repose etc and post compression parameters like hardness, weight variation, friability, disintegration time and in-vitro dissolution profiles . Among all the 5 formulation F4 is the best formulation because it show the high percentage of drug release in which was found to be 96.13% in 120 min and disintegration time was found to be 20 sec, as well as F4 formulation show the best results in every evaluation aspects. Key words: Telmisartan, chitosan, gellan gum, cross povidone, micro crystalline cellulose, sodium starch glycolate, Mouth dissolving tablets.

Last modified: 2016-07-24 00:26:00