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SYNTHESIS AND EVALUATION OF BIOLOGICAL ACTIVITY OF NEW ANTIMONY COMPOUNDS WITH METHOTREXATE
Journal: BEST : International Journal of Management, Information Technology and Engineering ( BEST : IJMITE ) (Vol.4, No. 7)Publication Date: 2016-07-31
Authors : ZAINAB K. ALI; SHAMS A. NADHUM; JALIL R. UGAL;
Page : 67-76
Keywords : Antimony Complexes; Methotrexate; Cytotoxicity; HeLa cell; RD Cell;
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Abstract
The aim of the present work is to synthesize two new antimony compounds containing Methotrexate (MTX) as a ligand, in the mole ratio 1:1 and 1:2. Antimony complexes were characterized by FTIR, UV, CHNS analysis, Atomic Absorption and conductivity measurements.
The biological activity of MTX, SbCl3 and the two new compounds was evaluated against Hela and Rhabdomyosarcoma (RD) cell lines. The four compounds were effective, while compound (2) gave the best inhibition.
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Last modified: 2016-08-16 20:02:45