PHARMACOLOGICAL EVALUATION OF SCIATILON SOFT GEL CAPSULE FOR ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY

Objectives: Aim of the present work was to investigate the anti-inflammatory and analgesic effects of Sciatilon Soft Gel Capsule. Material and Methods. The anti-inflammatory of Sciatilon Soft Gel Capsule was assessed by using the carrageenan induced paw oedema in rats. The hot plate test was performed to assess analgesic effects Potential in mice. Results: Among the doses Sciatilon Soft Gel Capsule (Sct) showed comparable activity with standard drug Indomethacine. Sct significantly (p < 0.05) reduced carrageenan induced paw oedema in a dose dependent manner. In hot plate method Sct 12mg/kg showed better analgesic activity than the other dose. POR showed comparable ulcer reducing potential (p<0.01) to that of standard drug Indomethacin (Ind) Conclusions: The results of this study demonstrated that Sciatilon Soft Gel Capsule 12mg/kg possesses biological activity that is close to the stand