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CLINICAL AND LABORATORY FEATURES OF HIV-INFECTION DEPENDING ON VIRAL TROPISM

Journal: Journal of the Grodno State Medical University (Vol.55, No. 3)

Publication Date:

Authors : ; ;

Page : 75-78

Keywords : HIV; tropism; clinical manifestations; AIDS; tuberculosis;

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Abstract

A comparative analysis of the clinical and laboratory manifestations of HIV infection was performed in two groups of patients: 62 patients infected with R5-tropic HIV variant and 35 patients infected with non R5-tropic variant of the virus. HIV tropism was determined by sequencing the gene V3 region of gp120 gene (FPR = 20%). We found no significant differences in the frequency of clinical stages of HIV infection (WHO, 2012), AIDS, opportunistic infections, mortality, the level of CD4 + and CD8 + lymphocytes and HIV viral load in patients infected with different HIV tropism. A longer length of HIV infection in patients infected with non R5-tropic variant of the virus was established.

Last modified: 2016-10-24 17:24:37