Wood Dust Exposure and Risk of Sinonasal and Nasopharyngeal Cancer: A Meta?Analysis

Objectives: In order to examine association between wood dust exposure and sin nasal and nasopharyngeal cancer. Methods: We performed a systematic search of the literature. Both random and fixed effects were used to calculate odd ratios (ORs) and 95% confidence intervals (95%CIs) of each study. Results: A significant increased risk of sinonasal and nasopharyngeal cancer was associated with wood dust exposure. The ORs for sinonasal cancer were 7.78 (CI: 2.97?20.25) among adenocarcinoma studies and 1.18 (CI: 0.64? 2.19) among squalors cell carcinoma studies. Contrary to women (OR=2.11, CI: 0.71?6.32), an elevated risk of sinonasal cancer was observed among men (OR=2.29, CI: 1.55?3.41). The OR for nasopharyngeal cancer was 1.87 (CI: 1.57?2.38). Conclusion: Wood dust exposure was a high risk associated with sinosnasal and nasopharyngeal cancer. Except for female and squalors cell carcinoma studies in sinosnasal cancer, all stratifications in our meta?analysis present a significant risk between sinosnasal or nasopharyngeal cancer and wood dust exposure.