Three Examples Illustrating the Good Performance of an Advanced Mathematical Modeling Method Based on the Theory of Dynamic Systems in Pharmacokinetics

The objective of the current study is to give three examples illustrating the good performance of an advanced mathematical modeling method based on the theory of dynamic systems in pharmacokinetics. The performance of the modeling method considered in the current study is illustrated in the following examples: 1) the first example illustrates the development of a mathematical model of the pharmacokinetic behavior of a drug administered orally; 2) the second example illustrates the determination of a physiologically realistic structure of the mean residence time of a drug administered orally; 3) the third example illustrates the development of a combined parent-metabolite mathematical model.