New features of postoperative analgesia

The article analyzes the methods of analgesia, including promising intranasal analgesia. The data of clinical efficacy and safety studies Aspriks drug. One of the current problems of intensive care is the lack of pain management after surgery. The majority of patients (80-90%) after surgery experience pain of moderate to unbearable for the first 2 weeks after surgery. Optimization of the route of administration of analgesic is a major factor in the effectiveness of postoperative analgesia. An interesting alternative formulations conventionally administered (intramuscularly, orally, intravenously) is intranasal administration. A comparative experimental study of the bioavailability and other parameters of ketorolac pharmacokinetics after a single intranasal administration to rabbits Ketorolac nasal sprays and SPRIX. Intranasal administration of Ketorolac and sprays SPRIX characterized by a prolonged absorption of ketorolac and longer circulating in the blood compared with intramuscular injection. In clinical trials, intranasal ketorolac ketorolok demonstrated high efficacy, rapid onset of analgesia and tolerability, especially in patients after major operatsiy. A result of the research, it was determined that the use of intranasal ketorolaka dramatically reduces the need for opioids. Based on “VAS” was significantly lower in the group ketorolaka throughout the 5 days of observation. Patients were assessed much higher quality of anesthesia for postoperative analgesia intranasal ketorolac.