Study Of Anorectic Activity Of Fluoxetine In Male Wistar Rats

Aims and objectives - To evaluate the anorectic activity of Fluoxetine in male Wistar rats.Materials and Methods - Fluoxetine is a selective serotonin reuptake inhibitor (SSRI). The anorectic activity of Fluoxetine was studied in freely feeding male Wistar albino rats after 14 days of drug administration.Rats were randomly allocated to 2 groups, the control and the treatment, each consisting of 6 animals. The treatment group was administered Fluoxetine 8 milligram per kilogram once daily orally for 14 days. The body weight of each animal in the 2 groups was assessed before and after the 14 days treatment. Similarly food intake of each animal in both groups was measured after 14 days drug administration. Then the animals were allowed a wash out period of 45 days after which the two groups were crossed over and the same parameters were studied.Results - The oral administration of Fluoxetine showed significant anorectic activity and reduction in the body weight compared to the control animals. The results were replicated by the observations after cross-over of the groups.Conclusion - The present study shows that Fluoxetine, an SSRI which is clinically used as an anti -depressant has significant anorectic activity in animal model.