FEATURES OF LIPID PEROXIDATION IN HYPERTENSION WITH OBESITY AND HYPERURICEMIA

This work studied the effect of uric acid on lipid peroxidation in patients with hypertension combined with obesity. The reserch involved 45 patients with hypertension of I-II stage and 1-3 degree increase of blood pressure. All patients had 1-2 degree obesity. Hyperuricemia was defined when uric acid level > 420 μmol / l in men and > 360 μmol / l in women. I analyzed the state of lipid peroxidation, activity of diene conjugates, malonic dialdehyde and total antioxidant activity of the blood. Besides, a marker of systemic inflammation ? C-reactive protein was determined. I have found that the balance of pro- and antioxidant systems deteriorates with the growth of uric acid from the normouricemia to hyperuricemia, and C-reactive protein increases.