FEATURES OF LIPID PEROXIDATION IN HYPERTENSION WITH OBESITY AND HYPERURICEMIAJournal: Journal of Clinical and Experimental Medical Research(JC&EMR) (Vol.1, No. 3)
Publication Date: 2012-10-15
Authors : Molodan D. V.;
Page : 341-346
Keywords : lipid peroxidation; C-reactive protein; hypertension; obesity; hyperuricemia;
This work studied the effect of uric acid on lipid peroxidation in patients with hypertension combined with obesity. The reserch involved 45 patients with hypertension of I-II stage and 1-3 degree increase of blood pressure. All patients had 1-2 degree obesity. Hyperuricemia was defined when uric acid level > 420 μmol / l in men and > 360 μmol / l in women. I analyzed the state of lipid peroxidation, activity of diene conjugates, malonic dialdehyde and total antioxidant activity of the blood. Besides, a marker of systemic inflammation ? C-reactive protein was determined. I have found that the balance of pro- and antioxidant systems deteriorates with the growth of uric acid from the normouricemia to hyperuricemia, and C-reactive protein increases.
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