Evaluation of oxidative stress markers in infertile women

Reproductive failure is a significant public health concern. Recently, ROS have been shown to have an important role in the normal functioning of the reproductive system and in the pathogenesis of infertility in females. Oxidative stress affects both natural and assisted infertility. Treatment that reduces OS may help infertile women with the disease that is caused by imbalance between free radicals and antioxidants. MDA is an end product of lipid peroxidation which can be used as a biomarker to measure the level of oxidative stress. TAC measures the low molecular weight non enzymatic antioxidants. Increase in MDA and decrease in TAC indicates an increase in oxidative stress. In the present study, it was observed that there was a statistically significant increase in serum MDA levels in female factor infertility and unexplained infertility when compared to controls. There was a statistically significant decrease in serum TAC in female factor infertility and unexplained infertility when compared to controls and statistically significant increase in serum LDH in infertile women with unexplained infertility compared to the control group and female factor infertility signifying the apoptotic damage in the unexplained infertility.