IN-SITU GEL SYSTEM BASED ON TEMPERATURE AND pH ACTIVATION FOR SUSTAINED OCULAR DELIVERY

The aim of the present investigational work was to develop an in-situ gel system based on chitosan and poly vinyl alcohol for ocular delivery of sparfloxacin. The hydrogel was developed by utilizing various concentration of chitosan and poly vinyl alcohol. The prepared hydrogel was characterized for pH, tonicity, viscosity, swelling and in-vitro drug release profile. Developed hydrogel underwent transition from solution to non-flowing hydrogel upon getting change of pH. In-vitro release of drug was observed spectrophotometrically which was upto 94% during six hours. The observed findings indicate that the proposed in-situ gelling system has substantial potential as ocular drug delivery. Keywords: In-situ gel system, Ocular delivery, Sparfloxacin, Chitosan, PVA.