SERUM URIC ACID LEVELS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Type 2 Diabetes mellitus( DM) is the predominant form worldwide accounting for 90 percent of cases. Cardiovascular disease (CVD) is most common cause of morbidity and mortality in Type 2 diabetic population .Hyperuricemia is a common finding in Type 2 Diabetes mellitus and increased uric acid levels represent an additional CVD risk factor. Uric acid is the final breakdown product of purine degradation in humans. Hyperuricemia results from increased production, decreased excretion or a combination of both. Hyperuricemia has been suggested to be a risk factor involved in the pathogenesis of vascular endothelial dysfunction and thereby plays a pivotal role in pathogenesis of various cardiovascular disorders. Hence the present study is done to estimate uric acid levels in Type 2 diabetics and compare with control group and to correlate uric acid level with FBS, TGL, HDL and Duration of diabetes. 50 clinically diagnosed cases of type 2 diabetes were selected as the study group and 50 age and sex matched healthy individuals taken as control group. The results were analysed by student t test and Pearson cofficient of correlation for serum uric acid, blood glucose and lipid profile. The mean uric acid levels in study group is significantly elevated than the control group. There is positive correlation between uric acid and FBS, TGL and duration of diabetes and negative correlation with HDL. To conclude hyperuricemia is significantly associated with type 2 diabetes mellitus. Serum uric acid level has an important role in the pathogenesis and progression of long term complications associated with diabetes especially cardiovascular diseases.