DESIGN AND OPTIMIZATION OF IMMEDIATE RELEASE TABLET OF SALBUTAMOL SULPHATE BY DIRECT COMPRESSION TECHNIQUE

This study is about a tablet, which disintegrates or dissolves quickly when placed in the oral cavity. Studies on formulation development of Salbutamol Sulphate Immediate Release Tablet, suitable for manufacturing by direct compression have been carried out. Trial formulations using various excipients were developed and evaluated for various qualities like hardness, friability, disintegration time, content uniformity and dissolution. Study concluded that Immediate Release Tablet of Salbutamol Sulphate can be prepared successfully with added patient benefit and increased consumer satisfaction. This article demonstrate recent advances in formulation development and processing technologies need the effort to achieve more sophisticated drug delivery system. The present study was carried out to meet the forgoing dialogue regarding the idea that Class III (high-solubility, low-permeability) compounds should also be eligible for a biowaiver as well as to improve patient compliance. The present invention is a rapid orally disintegrating pharmaceutical solid dosage form for water soluble but less permeable pharmaceutically active ingredient, combined with conventional pharmaceutical excipients and compressed into a tablet by using conventional pharmaceutical tabletting techniques. The use of organoleptically pleasing ingredients such as mannitol (mannitol has a negative heat of solution which further adds to the organoleptically pleasing nature of the formation); one obtains a dosage form which rapidly disintegrates and forms a watery slurry which is much more organoleptically pleasing and very easy to swallow.