FORMULATION AND IN-VITRO EVALUATION OF FLOATING MATRIX TABLETS OF NIZATIDINE

Floating matrix tablets of Nizatidine were prepared by using synthetic and natural polymers each in two different concentrations. The floating properties and in-vitro drug release properties were optimized and total 10 formulations were developed. The synthetic and natural polymers used were HPMC K4M, HPMC K15M and Guar Gum, Xanthan gum respectively. Each formulation consists of polymer in any one ratio of 1:0.6 or 1:0.8. In this study it was confirmed that the formulations containing Xanthan gum in 1: 0.6 ratio, have shown better floating properties and better in-vitro release properties.