PREPARATION AND EVALUATION OF ANTI HIV FLOATING DRUG DELIVERY SYSTEM

The purpose of present study was to formulate floating matrix tablets of Zidovudine , an anti HIV agent. Zidovudine floating tablets were prepared by direct compression method employing rate controlling polymers like both natural versus and synthetic Ethyl cellulose and Eudragit L- 100. The Prepared granules were subjected for pre compressional and drug excipient compatibility studies and tablets were evaluated for post compressional parameters such as weight variation, hardness, friability, drug content, invitro buoyancy studies and invitro dissolution studies. It was concluded that the out of all the formulations F8 was the best formulation as the extent of drug release was found to be 84 % upto 24 hrs with a floating lag time of 219 secs and the kinetics of drug release was follows first order kinetics with the ‘n’ value of morethan 0.5 indicates that non-fickian mechanism. With the formulations concluded that ehthylcellulose is having retarding the drug release form the matrix tablets when compared with the eudragit L- 100 because of its high swelling in nature. Floating lag time from all the prepared formulations was found to be in the following order: F1>F2>F3>F4>F9>F5>F6>F7>F8 and % Cumulative drug release from all the prepared formulation was found to be in following order F1>F5>F2>F6>F3>F7>F4>F9>F8. The kinetics of optimized formulation F8 was found to be follows first order kinetics and the ‘n’ is more than 0.5 indicates that it follows non-fickian mechanism. Endured super case II release, during the dissolution study, which indicated that polymer relaxation, had a significant role in the drug release mechanism. Drug release mechanism was case II non-Fickian (anomalous) release (0.5? n ? 0.89).