INFLUENCE OF SELECTED VARIABLES ON FABRICATION OF MUPIROCIN LOADED PLGA NANOCARRIERS

Aim of the study was to develop PLGA nanoparticles (PLGA-NP) of mupirocin (MP) and to study the effect of independent variables in order to optimize the formulation for effective delivery. Drug loaded PLGA-NPs were successfully prepared by nanoprecipitation method and characterized by mean particle size, zeta potential, entrapment efficiency, drug loading, drug release, TEM, and DSC study. Independent variables like drug-polymer ratio, surfactant concentration, and stirring speed showed significant effect on the dependent variables like particle size, entrapment efficiency and drug loading. The ANOVA results showed that selected independent variables had a significant effect on the preparation of mupirocin loaded PLGA-NP.