FERONIA ELEPHANTUM MODULATES ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION BY ANTIOXIDANT PATHWAY IN EXPERIMENTAL RATS

The present study evaluates Feronia elephantum alcoholic fruit extract (FEAFE) against isoproterenol induced myocardial infarction(MI), since, no studies have been reported to ascertain its cardio protective activity. Rats (n=6) were divided into five groups, namely, Group I: Normal control, Group II: ISO (200mg/kg s.c). Group III, IV, & V: FE (400 mg/ kg orally) and Vit E (50 IU /kg orally) respectively, administered for 21 day, by end of treatment isoproterenol was administered for two days except Group III. ECG was recorded after 21 days. Blood samples and histopathological studies of isolated heart were performed by biochemical estimations, respectively. Isoproterenol induced rats show increased ST segment, QRS complex and QT interval, besides significant increase in CK-MB, LDH, AST, ALT and Troponin-I levels. Further, they showed significant increased MDA level, decreased SOD, GSH, total protein level. Pre-treatment with FEAFE significantly restored above parameters, supported by histopathological data. Pretreatment with FEAFE modulates isoproterenol induced MI by antioxidant pathway in rats.