FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF CANDESARTAN CELEXETIL BY DIRECT COMPRESSION
Journal: Indian Drugs (Vol.54, No. 3)Publication Date: 2017-03-25
Authors : Dange Y.; Randive D.; Bhinge S.; Bhutkar M.; Wadkar G.;
Page : 23-27
Keywords : ;
Abstract
The objective was to develop optimized gastric floating drug delivery system (GFDDS) of candesartan celexetil floating tablets by using various polymers like Eudragit and MCC. In the present work, attempts have been made to prepare candesartan celexetil by direct compression method by using Citric acid, NaHCO3, Magnesium stearate, Eudragit and MCC. Formulations (F1 to F4) of floating tablets of candesartan celexetil were prepared using variable concentrations of Eudragit and MCC. The prepared formulations were evaluated for thickness, hardness, weight variation, friability, drug content and uniformity. The buoyancy lag time and the total floating time was studied for all the formulations. Formulation F4 of sustained release tablet of Candesartan celexetil containing a combination of both polymers was found to be the optimized formulation for 13 hours release as it fulfilled all the requirement of floating drug delivery system of sustained release dosage form.
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