ResearchBib Share Your Research, Maximize Your Social Impacts
Sign for Notice Everyday Sign up >> Login

Serotonin syndrome due to fluoxetine and tramadol in renal impaired patient

Journal: International Journal of Basic & Clinical Pharmacology (Vol.3, No. 1)

Publication Date:

Authors : ;

Page : 227-229

Keywords : Serotonin syndrome; SSRIs (Serotonin Reuptake Inhibitors); Opioids; Drug-drug interactions; CYP 450;

Source : Downloadexternal Find it from : Google Scholarexternal


Serotonin syndrome causes confusion or altered mental status; other symptoms include myoclonus, shivering, tremors, diaphoresis, hyperreflexia, incoordination, fever and diarrhoea. Tramadol possesses dual pharmacological effects i.e., a weak opiate agonist at mu, kappa and delta opiate receptors along with reuptake inhibition of norepinephrine and serotonin. Risk associated with tramadol increases when co-administered with serotonergic antidepressants or MAOIs (monoamine oxidase inhibitors) and in renal impaired. The incidence of this syndrome is less than 1% as most of the cases remain unreported. The case highlights the fact that interaction between serotonergic agents like fluoxetine and tramadol especially in the presence of co-morbid medical illness can lead to serotonin syndrome. [Int J Basic Clin Pharmacol 2014; 3(1.000): 227-229]

Last modified: 2014-02-08 13:51:08