INFLUENCE OF SERTRALINE ON HYPOGLYCEMIC EFFECT OF ORALLY ADMINISTERED PIOGLITAZONE AND ROSIGLITAZONE IN HEALTHY RABBITS

The present study was planned to study the influence of sertraline on hypoglycemic effect of orally administered pioglitazone and rosiglitazone in healthy rabbits. In the beginning of experiment, the rabbit were fasted for 18 hours with distilled water ad libitum. The blood was withdrawn from the marginal ear vein of pioglitazone (10 mg/kg, p.o.) treated rabbits and rosiglitazone (720 μg/kg, p.o.) treated rabbits at different time intervals at 0 h, 1, 2, 4, 8, 12, 18, 24 h before and after administration of sertraline (18 mg/ kg, p.o). The blood glucose was estimated by GOD-POD enzymatic kit method using semi-autoanalyzer and data were expressed in mg/dl. The results shown that sertraline increases the onset, peak effect and duration action of pioglitazone and rosiglitazone in healthy rabbits during concomitant administration of these drugs. In conclusion the dose and frequency of administration of sertraline with pioglitazone or rosiglitazone should be adjusted while administrating concurrently.