DESIGN AND CHARACTERIZATION OF BIODEGRADABLE TIZANIDINE NANOPARTICLES FOR IMPROVED ORAL BIOAVAILABILITY

Tizanidine HCl is a drug with poor water solubility, oral bioavailability and high first pass metabolism. The present study aims at developing a nano formulation by nanoprecipitation method to improve the oral bioavailability. Five formulations (F1-F5) with different polymer ratios were prepare and optimized on the basis of entrapment efficiency. In vitro release kinetics of formulations shows extended release of drug over a period of 128 h. Optimized formulation F3 shows better stability and oral bioavailability 3.6 times more than pure drug.