STUDY OF CD38 GENE EXPRESSION IN PATIENTS WITH COLON CANCER

Colorectal cancer (CRC) remains one of the most widespread malignancies in the world. According to the last global onco-epidemiological analysis, although, it has been estimated that worldwide there are 1.2 million new cases a year. Globally, CRC is the fourth most common cause of cancer related deaths in men and third in women, killing an estimated 320,600 men and 288,100 women annually. The conventional prognostic factors for patient survival are histologic tumor grade (differentiation) and tumor stage (TNM, tumors/nodes/ metastases, stages I–IV). CRC is less common in people under the age of 50 years, with the median age at diagnosis being 70. Mutations in several different genes seem to be needed to cause CRC.