EFFECT OF LIGHT REGIMES VIOLATIONS ON LIPID METABOLISM IN INTACT RATS AND ANIMALS WIHT ALIMENTARY OBESITY

Obesity is a widespread disease which causes profound metabolic disorders, decreased operability and increased risk of developing of complications such as diabetes, hypertension, heart failure, etc. These complications are largely due to metabolic disorders of lipid metabolism, increased number of atherogenic lipoproteins in plasma, reduced tissue sensitivity to insulin, which ultimately leads to the development of metabolic syndrome. The development of modern society has led to an increase in the rhythm of life, the work of factories 24 hours a day, forcing people to work at night, exposing to desynchronization of daily rhythms, associated with changes in light conditions, which is reflected in the functional indexes of the body, leading to a decrease in the total resistance of all systems, and the metabolism of the organism. The essence of desynchronosis is a mismatch in phase of circadian rhythms of the body, thus causing various violations of his well-being: sleep disturbances, decreased appetite, deterioration of health, mood, drop in operability, neurotic disorders, and even organic diseases (gastritis, peptic ulcer disease, and others). So, there is an interest in studying the effect of light deprivation on the functional indicators, reflecting the endurance to hypobaric hypoxia and maximum physical operability, as well as lipid metabolism in normal body weight and obesity. By analyzing the results, we found that under normal light mode, alimentary obesity in rats leads to increased body fat, hypercholesterolemia, hypertriglyceridemia, hyperglycemia, decreased resistance to hypobaric hypoxia and maximum physical exertion. Light deprivation weakens the disorders of lipid metabolism in obesity, but has a negative effect on the functional indicators of the animals' organism, reflecting endurance to maximum exertion and severe hypobaric hypoxia.