FORMULATION AND IN-VITRO EVALUATION OF GLIBENCLAMIDE DRY EMULSION IN VEGETARIAN CAPSULES

The purpose of this study is to improve the bioavailability and dissolution of Glibenclamide in the preparation of a dried emulsion. This dry emulsion formulation is filled in HPMC capsules as it is of vegetarian source but not gelatin because of several drawbacks. The animal source of gelatin may be a problem for some consumers, such as vegetarian and religious groups or ethical groups, since unmodified gelatin is subjected to cross linking in contact with aldehydes, solubility problems can be expected with certain fill formulations. Dry emulsions are prepared by the drying of liquid emulsions in which there is a solid form in the aqueous phase. The solid support provides the dry and bulk emulsions. In this preparation the emulsion was dried, sesame oil in which the drug is soluble, hydroxyl propyl methyl cellulose as the organic filler and Tween 80 as the surfactant is used. The dried emulsion was evaluated for the drug content, determination of the globular size and surface characterization, in vitro release of the drug in dry emulsion was studied by a type II USP-type paddle dissolving apparatus. This study revealed that the solid dry emulsion technique proved to be promising and useful for improving dissolution. Key Words: Glibenclamide, Dry Emulsion, HPMC capsules, Sesame oil