Pseudoepitheliomatous Hyperplasia in the Setting of CD30+ Lymphoproliferative Disease: A Histologic Mimic of Squamous Cell Carcinoma that Exhibits Indolent Clinical Behavior

There are reports of keratoacanthomas as well as pseudocarcinomatous hyperplasia (PEH) mimicking poorly differentiated squamous cell carcinoma arising in the setting of CD30+ lymphoproliferative disease. Although the prominent PEH noted in some individuals closely mimics squamous cell carcinoma on biopsy, the indolent clinical behavior indicates that this phenomenon is best considered a reactive change