SYNTHESIS OF 1-SUBSTITUTED-2- SUBSTITUTEDGUANIDINO-4-SUBSTITUTEDIMINE-6-THIO- 1,3,5-TRIAZINES
Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.04, No. 12)Publication Date: 2017-12-07
Authors : P. V. Raut P. S. Bodakhe S. A. Waghmare D. T. Tayade;
Page : 4293-4300
Keywords : SYNTHESIS OF 1-SUBSTITUTED-2- SUBSTITUTEDGUANIDINO-4-SUBSTITUTEDIMINE-6-THIO- 1; 3; 5-TRIAZINES;
Abstract
2-Substitutedguanidino-4-substitutedimine-6-substitutedimino-1,3,5-thia-diazines (VIIIa-r) were successfully isomerised into 1-substituted-2-sub-stitutedguanidino-4-substitutedimine-6-thio-1,3,5-triazines or 1-methyl-3-(1- substituted-4-{[(E)-substitutedmethylidene]amino}-6-thioxo-1,6-dihydro-1,3,5-triazin-2-yl)guanidines (IXa-r) by refluxing with 10% aqueous ethanolic sodium bicarbonate medium. The structure of all the synthesized compounds was justified on the basis of chemical characteristics, elemental analysis and spectral analysis.
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