PRECANCEROUS LESIONS OF PROSTATE A CLINICO-PATHOLOGICAL STUDY

Background: Prostate cancer is one of the most common malignancies diagnosed in men & is the most common cancer found in men older than 60 years. One third of all men older than 50 years have a latent form of prostate cancer that may progress to life threatening Prostate cancer. In this study all the precancerous lesions were more common in the higher age groups (60-69 and 70-79 years). Material And Methods: The present study has been performed on 100 patients in the department of Surgery , Eras Lucknow medical college and hospital. The age of the patients varied from 40-80 years. Maximum proportion of patients (34%) were aged between 60-69 yrs followed by 70-79 yrs (30%). There were 12% patients in age grp 40-49 yrs and 24% were in the age group of 50-59 years. Thus it was seen that the complaints of lower urinary tract system or prostatic disease were common in higher age group. Results: In this study all the precancerous lesions were more common in the higher age groups (60-69 and 70-79 years). However , no statistically significant association between type of lesion and age could be established in this study (p=0.267). Studying the histopathology only peripheral and central zones were seen to be involved. Peripheral zone was involved in 4/5 (80%) cases while central zone was involved in 1/5 (20%) cases Overall, in the present study, PIN was found to be an efficacious marker for prognosis of prostate carcinoma.