HEPATIC PRENEOPLASIA INDUCED BY N-NITROSODIMETHYLAMINE AND N-NITROSODIETHYLAMINE IN JAPANESE QUAIL EMBRYOS

Toxic and carcinogenic effects induced in ovo by N-nitrosodimethylamine and N-nitrosodiethylamine in Japanese quail embryos were studied by histopathological methods. The obtained results indicate that both compounds induce preneoplastic hepatic alterations. The spectrum of macroscopic and microscopic lesions identified in carcinogen-treated embryos has been presented. The significance of avian embryos as an inexpensive and reliable model system for studies on hepatocarcinogenesis has been briefly discussed.