A REVIEW ARTICLE ON ENDOTHELIAL DYSFUNCTION IN PATIENT WITH TYPE 2 DIABETES MELLITUS

The endothelial cells involved in modulating vascular tone and structure. Endothelial cells produce a vast range of causes that also regulate cellular adhesion, smooth muscle proliferations and vessel wall inflammation. Endothelial function is important for homeostasis of the body and its dysfunction is associated with several pathophysiology conditions like diabetes, atherosclerosis. Sufferers with diabetes at all times exhibit an impairment of endotheliumdependent vasodilation. Therefore, working out and treating endothelial dysfunction is the principle focus within the prevention of vascular problems associated with all types of diabetes mellitus. This review will focus on the pathophysiology, assessment and therapeutics that exceptionally target endothelial dysfunction within the context of diabetic setting. Pathophysiology including nitric oxide, oxidative stress, angII, diabetes will be discussed. Pharmacological approaches that upregulate endothelium derives nitric oxide synthase and treatment that might prevent the development of diabetes associated vascular complications will be discussed. Keywords: endothelial dysfunction, nitric oxide, nitric oxide synthase ,vascular smooth muscle cells, endothelialderived hyperpolarizing factors.