Effect of the tranexamic acid in reducing the blood loss in the Orthopaedic surgery

: Background - we investigated the effect of a single preoperative bolus dose of tranexamic acid (15 mgkg) on perioperative blood losses and packed cell transfusion requirements in patients scheduled for hemiarthroplasty surgery for fracture neck of femur.Patients and methods -Total of 36 patients taken in study . In 17 pts (Tranexamic acid group)a single bolus dose of 15 mgkg tranexamic acid was given preoperatively 15 min before the surgery. Data are collected from previously operated patients (19 pts-control group) where tranexamic acid was not given . We recorded per- and postoperative blood losses and transfusion requirements postoperatively. Results- There was significant difference in the intraoperative blood loss between the two treatment groups(Mean-TA264.88 ml, C 330.52 ml) .Postoperative blood loss were significantly less in the TA group (Mean- T207.05 ml, C329.68ml). Packed red blood cell transfusion requirements were significantly lower in the TA group compared with the control group. Conclusion-Tranexamic acid 15 mgkg given as a single preoperative bolus dose reduces intra operative and post operative blood loss, and packed cell transfusion requirements in hemiarthroplasty surgery.