Inhibition Activity of Alpha Glucosidase from Several Stem Bark of Raru

Ram is an additional compound used in the processingof toddy traditional beverage such as tuak (Batak's beverage).It is made from stem bark of certain species and is claimedto be a preservative as ivell as taste-enriching substance of the bevemge. Accordingto the local traditional knoivledge,ram also can reduce the level of blood sugar. The oijective of this study uere to explorespecies that are used toproduce ram, to determinetheir bioactivecompounds, and to investigate the effectiveness of ram extraaiues in reducing blood sugar level. The last oijective was approximatedfry evaluating the effectiveness of the substance to inhibit alpha glucosidase activity. Exploration atjive locations in North Sumatra resultedin fonrram-producing species, i.e. Corylelobinm melano:iglon Pierre, Corylelobium lanceolatum Craib, Sborea balanocarpoides Sym and Vatica peraeensis King. All of these ram-producing species contain jlavonoid, saponin and tannin, The crude extracts obtained from rejmx and maceration tmthod uerefound to be able to inhibit alpha glucosidal seactivity up to 88-97%. The crude extract of Shore balanocarpoides exhibits the best peiforfllance, with an Inhibiting bility equivalent topatented dmg (Gl11cobay).