Applicability of tetracycline and prednisolone elixir in management of multiple recurrent aphthous ulcers: An original study

Introduction: Present study was undertaken to evaluate application of swish and spit [elixir] technique of drug delivery for management of patients with multiple aphthous ulcers especially in large posterior lesions where topical appilication is difficult and cumbersome. Aim: The aim of present study was to check efficacy of tetracycline and prednisolone elixir in treatment of recurrent aphthous ulcers and check which drug among the two is better for prevention of recurrence of the lesions. Materials and Methods: A total of fifty patients were selected with recurrent aphthous stomatitis and divided in two groups Group A and Group B. Group A patients were asked to use tetracycline elixir and Group B patients used prednisolone elixir thrice a day for 15 days. Pain Severity, ulcer count and size of the ulcers were determined. Results: There was no statistically significant difference in study parameters Viz; pain Severity, ulcer count and size of the lesions in both group. However rate of recurrence of lesions was much low in prednisolone group as compare to tetracycline group. Conclusion: At the end of study it was concluded that both tetracycline and prednisolone elixir can be used for treatment of recurrent aphthous stomatitis. However prednisolone was better in terms of recurrence of lesion with less percentage of recurrent lesions.