TESTOSTERONE RAISES THE RATE OF OXYGEN CONSUMPTION BY THE TISSUE OF PROSTATE

We have significant experience of effective application of testosterone medications in men with chronic prostatitis (CP) and benign prostatic hyperplasia (BPH). But the critical analysis of literature and clinical data gives an opportunity to make the conclusion, that intimate, molecular mechanisms of clinical effectiveness of testosterone in men with CP and BPH still remain incompletely understood. The aim is to study how does testosterone impact on the rate of oxygen consumption (ROC) by the homogenates of rats' prostate. Materials and methods: 12 male rats were used. They were subdivided into two groups. The rats of the first group (6 animals) got the application of testosterone-containing gel – Androgel – before the surgery. The rats of the second group (6 animals) got no testosterone. Under anesthesia the prostate was resected from rats. Homogenate was prepared from every prostate. Further every homogenate was placed into the can, containing 250 ml of 0,9 % solution of NaCl. Then the oxygen-measuring device was placed into the can and the air-tightness was created. Each can was put into the thermostate for 30 minutes at 36,6 ºC. Then the measurement of the concentration of O2, dissolved in the water in the can, was made. It was detected, that the concentration of O2 decreases much faster and more remarkably in those experiments, when before the surgery the testosterone-containing gel was used (in rats of the first group). Conclusion: Testosterone raises the rate of oxygen consumption by the tissue of prostate. In such way, testosterone helps the prostatic tissue to consume О2 supplied by blood. We consider that this is the pharmacologial reason and the basis of efficasy of testosterone in men with chronic prostatitis and BPH.