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STUDY TO UNDERSTAND FACTORS GOVERNing DISSOLUTION OF PARACETAMOL TABLETS USING DESIGN EXPERt® SOFTWARE

Journal: Indian Drugs (Vol.55, No. 08)

Publication Date:

Authors : ; ;

Page : 31-37

Keywords : ;

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Abstract

In vitro testing is of paramount importance both in formulation development and in optimization of any pharmaceutical dosage form. Dissolution testing is a quality control test used to check batch to batch variability The main objective of this study was to determine the impact of various parameters like volume of the buffer used, the rotational speed of the paddle and temperature over the percentage drug release in a particular time frame. The collected data was analyzed using Design Of Experiments (DOE) software in order to optimize the dissolution parameters for the marketed paracetamol tablet formulation. A marketed batch of paracetamol tablets was used for the present study. The obtained results showed that the standard percent cumulative drug release was maintained even when the dissolution parameters were refashioned and thus provided a substantial waiver of exploitative use of water resources for the in vitro dissolution testing for paracetamol tablets making it a greener method.

Last modified: 2018-09-21 18:25:50