A Rare Case of Hemolytic Anemia

Anti c is an antibody against c antigen, which is one of the minor antigens of the Rh system. Anti-c antibodies are a rare cause of autoimmune haemolytic anemia in adults. Here we present a case of an adult female who presented with anemia in failure. Blood transfusion was planned for the patient but patient's blood could not be cross matched to the major ABO blood groups. Patient was transfused with least incompatible (O negative) blood and subsequently developed features suggestive of haemolytic anemia. Direct Coombs test was positive for warm type IgG antibody and Anti-c antibody was subsequently detected to be positive.