DIAGNOSIS AND TREATMENT OF EARLY STAGE PARKINSON'S DISEASE

Parkinson's disease (BP) is a progressive neurodegenerative disorder characterized by a combination of hypokinesia with muscle rigidity and / or resting tremor, as well as with later developing postural instability and a wide range of non-motor disorders, including autonomic, psychiatric, dissomantic and sensory symptoms. The formation of neurotoxic aggregates of a small presynaptic protein, alpha-sinuclein (the main component of Lewy's bodies), accompanied by the death of pigmented neurons of the ventrolateral sections of a compact part of the black substance, is considered to be the main link in the pathogenesis of PD. However, in recent years, it has been established that only the main motor symptoms of Parkinson's disease correlate with the lesion of the black substance, while the degenerative process in BP involves other groups of neurons in different regions of the brain, as well as in the peripheral nervous system, which underlies numerous non-motor manifestations of the disease [1, 3].