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Dipeptidyl Peptidase IV Inhibitory Activity of Berberine and Mangiferin: An In Silico Approach

Journal: International Journal of Clinical Endocrinology and Metabolism (Vol.3, No. 1)

Publication Date:

Authors : ; ;

Page : 018-022

Keywords : Berberine; Mangiferin; Sitagliptin; Vilda- gliptin; in silico and DPP-IV;

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Background: Dipeptidyl peptidase-IV (DDP-IV) Inhibitors may represent single anti-diabetic drugs, the multiple actions of which may translate into demonstrable therapeutic benefits in diabetes. The marketed synthetic DPP-IV Inhibitors are expensive drugs and have been reported to cause unacceptable adverse effects such as pancreatitis, angioedema, thyroid and pancreatic cancers. In this scenario, research to identify DPP-IV Inhibitors from alternative sources is desirable.

Last modified: 2019-01-11 18:04:08