The informative Value of Integral Intoxication Indices in Patients with Chronic Odontogenic Sinusitis of Maxillary Sinus

The purpose of the work was to identify the integral intoxication indices in patients with chronic odontogenic sinusitis of the maxillary sinus and to determine their diagnostic effectiveness. Material and methods. We conducted a retrospective study of 97 medical records of inpatients diagnosed with odontogenic sinusitis of the maxillary sinus. On the basis of the first general analysis of blood we calculated the following integral intoxication indices: leukocyte index of intoxication (LII) according to B. A. Rice; LII by Ya. Kalf-Kalif; leukocyte index of intoxication by V. K. Ostrovsky (LIIO); nuclear intoxication index (NII); leukocyte-granoulozitate index (LGI); the index shift of leukocytes bloods (ISLB); the index of correlation of leukocytes and monocytes (ICLM); the index of correlation of leukocytes and eosinophils (ICLE); the index of correlation of neutrophils and leukocytes (ICNL); the index of correlation of neutrophils and monocytes (ICNM). Results and discussion. At the first stage of the study, we determined the informative value of the LII by Ya. Kalf-Kalif for acute and chronic odontogenic sinusitis of maxillary sinus. χ2 was calculated between the values for acute and chronic process (χ2 = 0.24; p = 0.622). This led to the conclusion that there was no significant difference in the value of this index in acute and chronic course of the disease. Therefore, the LII by Ya. I. Kalk-Kalif was equally informative both for acute odontogenic sinusitis of maxillary sinus and for the chronic one. The second stage of the study consisted in a comparative evaluation of the values of the LII Ya. Kalf-Kalif by means of χ2 and the Fisher criterion. The third stage of the study included the determination of the homogeneity of the sample of patients in the group according to the data of two isolated integral indices of intoxication (ISNM and ISLM). For this, the McNimar statistical criterion (χ2m-n) was calculated. The results indicated a significant difference in the data (in group 2, we revealed significant differences between the indices of the ISNM and ISLM in different patients). Conclusions. The results represent a fundamentally new data identifying informative value for this form of the disease index of intoxication ISNM based on modern statistical methods and principles of evidence-based medicine. Moreover, the study objectively proves the presence of significant endogenous intoxication identifying significant differences in the change of indexes LII by Ya. Kalf-Kalif and ISNM for patients with chronic odontogenic sinusitis of the maxillary sinus. The latter can cause generalization of the infectious inflammatory process.