Antimicrobial activities of Irvingia gabonensis Leaf against diarrhoea Causing Agents

Antimicrobial effect of Irvingia gabonensis leaf extracts was tested against bacteria and fungal agents that causes diarrhoea (Salmonella typhi, E.coli, Staphylococcus aureus, Shigella dysenteriae and Candida albican). Fresh tender leaves of Irvingia gabonensis was collected, air-dried, grounded and soarked in n-hexane, methanol and aqueous solvents. The Antimicrobial activities were determined using agar well diffusion assay, then the MIC, MBC and MFC were determined by agar dilution assay. The results revealed that the crude methanol and n- hexane extracts of Irvingia gabonensis produced the highest antifungal effects against Candida albicans with the MIC of 25 mg/ml and MFC of 50 mg/ml. The crude aqueous extract of I.gabonensis had no antifungal activity on Candida albicans. The crude methanol extracts of Irvingia gabonensis produced the highest antibacterial effects with MIC ranged of 6.25 mg/ml to 25 mg/ml and MBC of 12.5 mg/ml to 50 mg/ml. These results suggest that Irvingia gabonensis leaf extract is recommended as a diarrhoea disease remedy.