Using Bioinformatics to Study Homology Between Herpes Simplex Virus Type 1 Glycoprotein C Gene and Herpes Simplex Virus Type 2 Glycoprotein F Gene | Biomed Grid

Bioinformatics is an interdisciplinary field mainly involving molecular genetics. computer science, mathematics, and statistics. Data intensive and large-scale biological problems are addressed from a computational point of view. The most common problems are modeling biological processes at the molecular level and making inferences from collected data. In this study we used bioinformatics as a tool to study homology between Herpes simplex virus type 1 glycoprotein C gene and Herpes simplex virus type 2glycoprotein F gene. In the beginning we used the Gene data Bank to get the DNA sequence. Then we used a program Blast and got a percentage alignment 81%. We used protein data bank (PDB) to estimate the structure of the expressed proteins that were tertiary (three dimensional) structure that harbor both α helices and β pleated sheets. Finally, we used “PHYRE2 “protein folding recognition set to visualize, analyze and manipulate the resulted 3D protein model