A RARE CASE OF HYPERTRIGLYCERIDEMIA-CASE REPORT

Familial hypertriglyceridemia is one of the uncommon genetic dyslipidemias characterised by the triad of elevated plasma triglycerides (more than 90th percentile), normal or only mildly increased cholesterol (less than 90th percentile) and reduced plasma levels of HDL. The discovery of hypertriglyceridemia should prompt an investigation for s e c o n d a r y c a u s e s s u c h a s Hypothyroidism, Hepatitis, Sepsis, Renal failure, and Diabetes mellitus. In addition patients should be evaluated for other components of metabolic syndrome like o b e s i t y , h y p e r t e n s i o n a n d i n s u l i n resistance. Hypertriglyceridemia is classified as primary hypertriglyceridemia when there are no secondary causes identified. Primary hypertriglyceridemia is the result of various genetic defects leading to disordered triglyceride metabolism. Familial hypertriglyceridemia type V is common in adults with a prevalence of 1 in 500.Familial hypertriglyceridemia type V with genetic defects in APOA V and GPIHBP1 are reported to have an incidence of less than 1 in 1 million. We are reporting a case of Familial hypertriglyceridemia type V. ABBREVIATION GPIHBP1-Glycosyl Phosphatidyl Inositol-anchored High density Lipoprotein Binding Protein 1.