SIGNIFICANCE OF VITAMIN D DEFICIENCY IN THE FORMATION OF BRONCHIAL OBSTRUCTIVE SYNDROME IN CHILDRENJournal: NAUKA MOLODYKH (Eruditio Juvenium) (Vol.7, No. 2)
Publication Date: 2019-06-30
Authors : N.A. Belykh; V.V. Amelina;
Page : 261-273
Keywords : vitamin D; children; acute respiratory infections; wheezing; prevention;
The literature published over the last decades indicates increasing awareness of vitamin D's multidirectional action in the human body. Evidence from large scale studies contributed to the understanding of vitamin D deficiency being a significant risk factor for many diseases. Receptors to vitamin D (VDR) are identified in more than 40 target tissues. Vitamin D may modify immune function, cell proliferation, differentiation and apoptosis. Vitamin D deficiency has been associated with numerous consequences for health, including rickets in children or osteomalacia in adults, increased risk of cancer, autoimmune diseases, infectious diseases, type 1 and type 2 diabetes mellitus, arterial hypertension, cardiovascular pathology and other diseases. Vitamin D regulated genes code for antimicrobial peptides providing protection against bacteria, viruses and fungi. The role of vitamin D deficiency in the predisposition of children to frequent respiratory diseases including those with broncho-obstructive syndrome has been actively studied in recent decades. To date, it has been proven that children with vitamin D deficiency have a greater risk of respiratory infections. It was demonstrated that administration of vitamin D to children with recurrent wheezes as adjuvant therapy in parallel with inhalation glucocorticoids, reduces the risk of exacerbation of wheezing caused by respiratory infections. However, antenatal hypovitaminosis D prophylaxis does not affect the frequency of this pathology. Vitamin D status is estimated by blood concentration of 25(OH)D. Currently, the prevalence of vitamin D deficiency in the population reaches an epidemic level, incl. in Russia. The results of a multicentre study «Rodnichok» showed insufficient vitamin D levels in 48% and the deficit in 90.8% toddlers in different cities. According to numerous studies, the use of the recommended preventive doses of vitamin D is insufficient to implement the «non-classic» functions of vitamin D. Thus, to date, the understanding of the role of vitamin D in the body has significantly expanded, but the possibility of using vitamin D in a complex of preventive measures and adjuvant therapy infections with wheezing, requires further scientific research.
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Last modified: 2019-07-02 20:51:49