GEL LOADED DENTAL IMPLANT: A DEMIURGIC DRUG DELIVERY SYSTEM FOR TREATMENT OF GINGIVITIS

The main objective of the project was to develop a dental implant for the patients suffering from oral gingivitis caused by bacterial infection, trauma etc. Person suffering from Gingivitis has chance to miss the medication during travel. For optimization of formula for the gel six batches were taken in which different amount of drug and polymer were added and observation were recorded. Six batches of gel were prepared by changing the polymer ratio. Six batches of gel were prepared by changing the polymer ratio. Three batches consist of carbopol whereas three batches consist of chitosan. Triclosan was added in all gel was subjected to in-vitro characterization it was observed that the in case batches containing chitosan, the gel formed by hazy and it contain come particulate matter also whereas the gel formed in case of carbopol were clear. Formulation f1 and f2 were less viscous and gel did not formed completely whereas formulation f4, f5, and f6, the gel formed was also less viscous as well as hazy. This could be due to the incorporation of chitosan in f4, f5, and f6 formulation which derived from chitin and it may not imbibe large amount of water to result in formulation of efficient gel. Obtained formula (f3) was characterized and it was found that viscosity of gel (f3) was highly viscous whereas drug content was 91.48%. The gel was subjected to in-vitro drug release it was found that 59% drug was released in the end of 72 hr. This may be due to the efficient gel forming capacity of carbopol which was further enhanced by incorporation of triclosan. Formulation F3 was selected as optimum formulation with desired properties and was subjected to further studies.