The Optimal Volume of Epidural Blood Patch in Treating Post-Dural Puncture Headache: a Mini-Review

Post-dural puncture headache is the major morbidity after intentional or unintentional dural puncture procedure, with CSF leakage and subsequent decrease intracranial pressure. An autologous epidural blood patch remains the most effective treatment and the option after failure of conservative treatment. The optimal blood volume of the epidural blood patch remains indeterminate, range from 5 to 30 mL. This mini-review aimed to review current evidence and literature of the blood volume injected into epidural space with the highest success rate, low repeated epidural blood patch procedure, and low complication rate.