EVALUATION OF DIURETIC ACTIVITY OF MILLETTIA PINNATA IN RATS

The purpose of the present study was to evaluate the diuretic activity of Millettia pinnata in experimental animals. Randomly selected animals were divided into five groups of six animals each. The various extracts of the bark of Millettia pinnata, that is, petroleum ether, ethyl acetate and methanol extracts were administered orally at a dose of 50 and 100 mg/kg. Parameters like volume of urine, pH of urine, conductivity and urinary electrolyte concentrations like sodium, potassium and chloride were studied and compared with the standard furosemide. The methanol extract of Millettia pinnata increased the urine output in a dose-dependent manner than petroleum ether and ethyl acetate extracts, whereas petroleum ether extract was significant when compared to ethyl acetate extract. From the present study, it can be concluded that Millettia pinnata has diuretic property.